Patti LuPone grew up in a house on Long Island where music was practically a member of the family. Her mother favored opera and musicals while her father leaned toward jazz, but there was always something playing.

As an adult, Ms. LuPone is a giant in the musical theatre world, and the two-time Tony-winning performer is coming to the Vineyard and bringing some of her favorite songs with her. Ms. LuPone will perform her show Don’t Monkey With Broadway on Friday, Sept. 2 as the final performer in this summer’s Broadway at the Performing Arts Center series.

Fresh off the Chicago’s Goodman Theatre’s stage from the new musical War Paint where she played cosmetics pioneer Helena Rubinstein, Ms. LuPone will explore her life in musical theatre through song.

Don’t Monkey with Broadway is a continuation of Shoulda, Woulda, Coulda, a concert show where Ms. LuPone sang songs no one expected her to sing from Broadway. It was all about songs she related to, no matter their intended singer.

“Gender didn’t matter, age didn’t matter, I like singing the songs I like to sing,” she said in a recent phone interview.

Songs to expect include Don’t Cry For Me, Argentina, The Ladies Who Lunch and other classic show tunes. Music director Joseph Thalken will be at the piano.

Ms. LuPone’s natural inclination in performing is big, but she is a flexible performer who can scale back when the medium calls for it, like television.

“It doesn’t really change anything, the interpretation of the character is the same,” she said. “It’s the physical largeness or smallness that you have to adjust.”

Performing to the balcony is one thing when you are in a musical bolstered by an ensemble, but a small concert requires different skills.

“I think the concerts are more difficult because you don’t have a character to hide behind,” she said.

Though it all started with music for Ms. LuPone, it’s now really all about the stage.

“I know I’m built for the stage,” she said. “I just know that’s where I belong.”

Patti LuPone performs on Friday, Sept. 2 at 7:30 p.m. at the Performing Arts Center. Tickets are available at vineyardbroadway.com.